well, good news is: it works. Bad news is, it borks my window manager. After so many attempts, I am forced to admit defeat. So, at least a few of my different methods that I tried did work, but with that comes a problem that my window manager does not want to run on my discrete GPU and then I get a bare desktop with no panels or proper windows.
Quake does launch correctly at that point but I rather have the rest of my DE actually function, and I did figure out how to set individual applications to launch on the second GPU. I’ll consider this solved for my use case… This combo of intel onboard graphics and AMD GPU was always my headache with this machine even in the times of windows.
All of them? I’ve always liked (and preferred) Linux for dev work, as I’m just so comfortable around working with the commandline and installing packages that I might need. For that end, any of them would work, you’d just need to set them up with what you want. If you wanna be “cool” and “hacker” you could install Arch and install every last package manually handpicked, or you could go with the most bog standard Ubuntu or Fedora or OpenSUSE. All of them work, it’s only down to your tools. If you like Kali, stick with it.