The problem is that modern DRM/anti-cheat often works at the kernel level, or by scanning the entire filesystem and running processes. They don’t work on linux by design, so the main route to compatibility is showing that there are enough people gaming on linux that they should seek other options for DRM and anti-cheat
Unfortunately very high, especially with modern systems using “trusted platform module” (TPM) hardware that can tell the software exactly what’s running, at a higher privilege level than the OS