Thanks this is a lot of great detail on the dosing mechanism that I think is really interesting. I love reading up on the experimental details and the actually components used to make these experiments work.

300mg of orally ingested THC spread out over 24 hours is about equivalent to consuming 1 typical candy/gummy every hour for 24 hours of the day. A reasonable or average or normal person would be uncomfortably high at these dosages. I also imagine the bioavailability of oral ingestion is less than the dosing mechanism you described although I’m not sure (is that getting taken up through the lymphatic system? How does it differ from oral ingestion or injection into the bloodstream?).

Fascinating stuff, thanks for sharing your knowledge.

Maybe I’m misreading the only plot that mentions dosing numbers anywhere. It looks like the largest dosing group is getting 3mg/kg/day. That’s a lot scaled up to a 100kg person (like 10x a normal gummy for example).

Just the American ones though, right? 🤣

I found this repo interesting just for the sake of centralizing a lot of useful info around VHS. Even if you don’t follow this path, the knowledge might help: https://github.com/oyvindln/vhs-decode

It’s literally the tech bro news site, though, by design. This criticism is ridiculous. YCombinator is the organization that funds so many Silicon Valley tech dreams.